Table 2.

Monoamine levels in tissues from experimental mice

	WT-CON	GULO-CON	GULO-SCV	ANOVA F value
Cortex
Dopamine	14.88 ± 3.60	22.56 ± 4.64	8.69 ± 3.08	F =3.29, p=0.057
DOPAC	3.87 ± 0.61c	4.00 ± 0.63c	1.45 ± 0.32d	F =7.07, p<0.01
HVA	3.81 ± 0.44a	4.43 ± 0.51a	2.34 ± 0.38b	F =5.73, p<0.01
3-MT	2.36 ± 0.37a	2.99 ± 0.56a	0.95 ± 0.24b	F =6.34, p<0.01
Norepinephrine	4.47 ± 0.23	4.79 ± 0.30	4.71 ± 0.27	F =0.39, p=0.68
Serotonin	4.51 ± 0.39	5.29 ± 0.37	5.39 ± 0.47	F =1.36, p=0.28
5-HIAA	4.38 ± 0.37e	4.18 ± 0.34e	2.40 ± 0.18f	F =12.62, p<0.001
Striatum
Dopamine	95.88 ± 12.90	130.16 ± 17.91	118.64 ± 14.81	F =1.29, p=0.30
DOPAC	12.87 ± 1.88	12.62 ± 1.85	8.15 ± 0.78	F =2.80, p=0.083
HVA	13.80 ± 1.27	16.51 ± 1.94	12.39 ± 1.04	F =2.033, p=0.16
3-MT	11.63 ± 1.73	14.23 ± 1.74	11.40 ± 1.38	F =0.94, p=0.41
Norepinephrine	2.92 ± 0.41	4.25 ± 0.67	3.08 ± 0.37	F =2.093, p=0.15
Serotonin	8.08 ± 0.43a	10.41 ± 0.88b	7.63 ± 0.56a	F =5.29, p<0.05
5-HIAA	6.45 ± 0.52c	7.52 ± 0.48c	4.20 ± 0.33d	F =14.03, p<0.001

Data reported are group mean ± S.E.M. F values refer to results of initial omnibus analysis of data. Columns with different subscripts show differences between specific groups as revealed in follow-up comparisons

^a,bp<0.05;

^c,dp<0.01.