Table 4.

Tumor promoter genes downregulated in resistant breast cancer (MCF-7/ADR) cells following sequential treatment with decitabine and doxorubicin with reference to decitabine alone treated cells for 72 h.

No	Gene Symbol	Entrez Gene I.D	Description	Sub cellular location	Function	Comments
1	CCL20	6364	Chemokine (C-C motif) ligand 20	Secreted	Chemoattractant of CCR6 bearing dendritic cells	Promote cell proliferation and metastasis. Also plays a role in organ specific metastasis of colorectal cancer55
2	CTSL	1514	Cathepsin L1	Lysosome and extracellular	Protein degradation and extracellular matrix (ECM) degradation	Due its ability to degrade ECM over a wide range of pH, it plays a key role in metastasis of tumor cells56
3	HDGFL1	154150	Hepatoma derived growth factor like 1	Secreted	Exogenous mitogen	Involved in anchorage independent growth, invasion and angiogenesis of non-small cell lung cancer cells57
4	HSPA2	3306	Heat shock 70kDa protein 2	Cytoplasm and nucleus	Molecular chaperone for CDC2	Promotes tumor promotion, migration and invasion58
5	LOC342897	342897	Non- specific cytotoxic cell receptor protein 1 homolog (zebra fish)	Intracellular	Ubiquitin ligase	Enhances cell proliferation of various cancers59
6	MAP7	9053	Microtubule-associated protein 7	Cytoplasm	Stabilize microtubules	Higher expression of MAP7 was associated with poor prognosis. Plays a role in cell division, motility and cell shape60
7	MMP9	4318	Matrix metallopeptidase 9	Extracellular, secreted protein	Proteolysis of ECM	Tumor invasion and metastasis61
8	NNAT	4826	Neuronatin	Endoplasmic reticulum	Regulates intracellular calcium levels in dendrites	Increases cell proliferation and decreases patient survival in Glioblastoma Multiforme62
9	NMB	4828	Neuromedin B	Extracellular, secreted protein	Involved in various physiological functions: exocrine and endocrine secretions, smooth muscle contraction	Angiogenesis and growth of malignant tumor cells63
10	RPL10L	140801	Ribosomal protein L10-like	Intracellular, cytoplasm and ribosome	Could play a role in sperm differentiation and maturation	Possibly enhance ribosomal activity and/or translational activity in ovarian cancer64
11	STMN3	100174566	Stathmin-like 3	Golgi apparatus	Microtubule depolymerization	Induce cell proliferation, migration and matrix invasion of adenocarcinoma and squamous cell carcinoma65
12	TKTL1	8277	Transketolase-like 1	Cytoplasm and nucleus	Transketolase metabolism	Enhances oxygen independent glucose metabolism and lactate based matrix degradation to favor tumor invasion and metastasis66