. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Mol Cell Neurosci. 2012 Nov 10;52:128–139. doi: 10.1016/j.mcn.2012.11.007

Table 1.

Different functions during collicular development require unique Pitx2 dosage. Left side of table lists developmental functions. Mouse genotypes at top of table are in order from highest Pitx2 dose (left) to lowest (right). Green boxes indicate a normal phenotype, yellow indicates an intermediate (int) phenotype, and red boxes indicate abnormal phenotypes. The box referencing MTT formation in Pitx2^−/− embryos refers to results from E18.5 conditional Pitx2 knockout embryos.

	Pitx2 dosage

Function	Pitx2^+/−	Pitx2^Δc/+	Pitx2^Δc/Δc	Pitx2^Δab/Δab	Pitx2^Δab/−	Pitx2^−/−
Midbrain GABAergic differentiation	nl	nl	nl	nl	nl	negative
MTT formation	nl	nl	nl	nl	absent	absent
Midbrain neuronal migration	nl	nl	nl	interm	disrupted	disrupted