Skip to main content
. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2012 Nov 8;53:531–556. doi: 10.1146/annurev-pharmtox-032112-135923

Figure 7.

Figure 7

Two major types of symmetric dimer interfaces observed in GPCR structures. A representative structure of dimer interface A with contacts via helices I, II, VIII is shown here for κ-opioid, PDB code 3DJH (36) (orange and magenta show receptor, the JDTic ligand is shown by spheres with white carbons). Interface A has been also observed within μ-opioid, rhodopsin and opsins structures. Another cluster of dimer interfaces B involves contacts via helices IV, V, VI (cyan and yellow) and is shown here for the CXCR4 complex with peptide antagonist PDB code 3OE0 (33). Similar orientation of subunits has also been observed in μ-opioid structure, PDB code 3DKL (34), with an extensive interface formed via helices V and VI.