Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2012 Jun 28;59:85–91. doi: 10.1016/j.freeradbiomed.2012.06.025

Figure 2. Cellular effects of oxidative stress and lipid peroxidation.

Figure 2

The non-enzymatic free radical generation of reactive aldehydes by lipid peroxidation occurs near lipid-rich cellular membranes and produces both membrane-bound and free electrophiles. These electrophilic species go on to modify proteomic and genomic processes. Antioxidant responses such as glutathione conjugation play a role in defending against the damaging effects of these reactive aldehydes. (LPO, lipid peroxidation)