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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Clin Immunol. 2012 Aug 29;33(1):162–171. doi: 10.1007/s10875-012-9767-z

FIG. 3. Molecular modeling of CFI mutations.

FIG. 3

a, Domain structure with the positions of mutations associated with recurrent infections, aHUS, and AHLE [4–6, 12–16]. Mutations are numbered inclusive of the signal peptide (+18 relative to position numbers when the signal peptide is excluded) [13]. b, Structure of human FI [17] with AHLE mutations (red spheres) c. Structure with aHUS mutations (red spheres). Molecular images generated by PyMol [41]. FIMAC, Factor I/membrane attack complex; SRCR, scavenger receptor cysteine-rich