Table 1.
Baseline characteristics and hormone measures of ovarian reserve of breast cancer and healthy participants
| Breast cancer participants (N=108) | Healthy participants (N=99) | p-value | |
|---|---|---|---|
|
| |||
| Age, Median (IQR) | 40.2 (5.5) | 33.0 (4.6) | <0.001a |
| <35 N(%) | 11 (10) | 63 (63) | |
| 35–39 N(%) | 27 (25) | 29 (29) | |
| >40 N(%) | 70 (65) | 7 (7) | |
|
| |||
| Race and ethnicity (%) | 0.002b | ||
| Caucasian | 77 (72) | 86 (87) | |
| African American | 13 (12) | 5 (5) | |
| Asian | 8 (7) | 4 (4) | |
| Hispanic | 9 (8) | 0 (0) | |
| Other | 0 (0) | 4 (4) | |
|
| |||
| Regular menses (%) | 96 (89) | 88 (88) | 0.96b |
|
| |||
| Prior pregnancy (%) | 72 (67) | 58 (59) | 0.20b |
|
| |||
| Gravidity, Median (IQR) | 2 (3) | 1 (1) | <0.001a |
|
| |||
| BMI, Mean (SD) | 25.3 (5.9) | 25.1 (5.9) | 0.84d |
|
| |||
| Current cigarette smoking (%) | 6 (6) | 1 (1) | 0.12 |
|
| |||
| Breast cancer type (%) | |||
| Ductal | 97 (90) | ||
| Lobular | 4 (4) | - | - |
|
| |||
| Cancer stage (%) | - | - | |
| 0 | 5(5) | ||
| I | 33 (30) | ||
| II | 50 (46) | ||
| III | 19 (18) | ||
|
| |||
| Estrogen or progesterone receptor positive (%) | 72 (66) | - | - |
|
| |||
| BRCA status (%) | |||
| Positive | 10 (9) | - | - |
| Negative | 38 (36) | ||
| Unknown | 59 (55) | ||
|
| |||
| AMH (ng/ml), Geometric mean (SD) | 0.66 (3.5) | 1.1 (2.9) | <0.001d |
|
| |||
| AMH below limit of detectability (<0.17 ng/mL), n (%) | 21 (19) | 7 (7) | 0.009b |
|
| |||
| FSH (mIU/ml), Geometric mean (SD)e | 7.7 (2.4) | 7.3 (1.5) | 0.52d |
|
| |||
| InhB (pg/ml), Geometric mean (SD)e | 27.7 (3.0) | 30.9 (1.8) | 0.45d |
a
Wilcoxon ranksum test
b
Chi-square test
c
Fisher’s exact test
d
Student’s t-test
e
Restricted to participants with estradiol levels ≤ 80 pg/mL(45 breast cancer and 91 healthy participants)