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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Nat Med. 2012 Dec 23;19(1):74–82. doi: 10.1038/nm.3040

Figure 4. Downregulation of miR-424 and miR-503 in PAH is associated with increased FGF2 and FGFR1 expression.

Figure 4

(a) Expression of miR-424, miR-503, and FGF2 mRNA in PAECs of controls and PAH subjects. *P < 0.01, **P < 0.05. (b) Correlation plots for expression levels of APLN mRNA and miR-424, miR-424 and miR-503, FGF2 mRNA and miR-424, and FGFR1 mRNA and miR-424 in PAECs from control and PAH PAECs. (c) Expression of FGF2 and FGFR1 proteins in control and PAH PAECs. (d) FGFR1 expression (shown in red) in control and PAH lung microvascular endothelium with costaining for vWF (shown in green). (e) Expression of miR-424 and miR-503 by in situ hybridization (shown in red) in the pulmonary endothelium (vWF staining in green) in the microvasculature of control and PAH lungs. Scale bar = 50 μm.