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. Author manuscript; available in PMC: 2013 Jan 9.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2012 Oct 8;53:187–210. doi: 10.1146/annurev-pharmtox-011112-140204

Figure 1.

Figure 1

The evolution of protein kinase A (PKA) anchoring models. (a) Schematic diagram (circa 1990) (18) presenting a model of the anchored RII complex. (b) Contemporary model based on the crystal structure of RIIα1–45 dimer in complex with the A-kinase anchoring protein (AKAP)–in silico binding helix (36, 48).