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. Author manuscript; available in PMC: 2013 Jan 9.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2012 Oct 8;53:187–210. doi: 10.1146/annurev-pharmtox-011112-140204

Figure 2.

Figure 2

Combinatorial assembly of cardiac A-kinase anchoring protein (AKAP) signaling complexes. The common name (first column) and alternate name(s) (second column) of each anchoring protein are indicated. Schematic representations of cardiac AKAPs highlight enzyme-binding sites and functional domains (third column). Binding partners are indicated (fourth column). Abbreviations: AC, adenylyl cyclase; AMP, adenosine monophosphate; βAR, β-adrenergic receptor; DH, Dbl homology domain; ERK, extracellular signal-regulated kinase; HIF-1α, hypoxia-inducible factor 1α; IP3-R, inositol 3,4,5-phosphate receptor; KCNQ, KvLQT potassium channel subunit; KSR-1, kinase suppressor of Ras1; Lfc, Lbc first cousin; MEK, mitogen-activated protein kinase kinase; MT, mitochondrial transit peptide; NCX1, sodium-calcium exchanger 1; NFATc, nuclear factor of activated T cells; NMDA-R, N-methyl-d-aspartate receptor; PDE, phosphodiesterase; PDK1, phosphoinositide-dependent kinase-1; PH, pleckstrin homology domain; PKA/C/D/N, protein kinase A/C/D/N; PP1/2A/2B, protein phosphatase 1/2A/2B; PTPD1, protein tyrosine phosphatase D1; RGS, regulator of G protein signaling; RSK, ribosomal S6 kinase; RyR2, ryanodine receptor 2; SAP97, synapse-associated protein 97; Siah2, seven in absentia homolog 2; Trek-1, two pore-domain potassium channel; TrpV1, transient receptor potential cation channel V1; VHL, von Hippel–Lindau protein.