Table 2.
Fiber Tracts and Measurements |
Descriptive (N = 32) |
FMR1 mRNA as a Predictor (N = 32) |
FMRP as a Predictor (N = 27) |
|||||||
---|---|---|---|---|---|---|---|---|---|---|
Age |
FMR1 mRNA |
Age |
FMRP |
|||||||
Mean | SD | Partial r2 |
P | Partial r2 |
P | Partial r2 |
P | Partial r2 |
P | |
Left Arcuate Fasciculus Complex | ||||||||||
Tract volume | 2,453 | 640 | 0.08 | 0.12 | 0.01 | 0.56 | 0.07 | 0.20 | 0.00 | 0.46 |
FA | 0.46 | 0.024 | 0.06 | 0.20 | 0.34 | <0.001− | 0.11 | 0.10 | 0.19 | 0.03 |
MD | 0.79 | 0.027 | 0.14 | 0.03 | 0.29 | 0.002+ | 0.14 | 0.06 | 0.14 | 0.04 |
Right Arcuate Fasciculus Complex | ||||||||||
Tract volume | 1,937 | 462 | 0.15 | 0.03 | 0.02 | 0.41 | 0.14 | 0.06 | −0.02 | 0.61 |
FA | 0.46 | 0.028 | 0.16 | 0.03 | 0.15 | 0.03 | 0.25 | 0.010− | 0.14 | 0.27 |
MD | 0.79 | 0.032 | 0.17 | 0.02 | 0.13 | 0.05 | 0.24 | 0.011+ | 0.20 | 0.02 |
Left Anterior Cingulum | ||||||||||
Tract volume | 163 | 57 | 0.00 | 0.97 | 0.05 | 0.22 | 0.02 | 0.51 | 0.16 | 0.05 |
FA | 0.60 | 0.065 | 0.05 | 0.21 | 0.14 | 0.04 | 0.09 | 0.14 | 0.17 | 0.03 |
MD | 0.78 | 0.062 | 0.11 | 0.06 | 0.13 | 0.05 | 0.01 | 0.55 | −0.08 | 0.87 |
Right Anterior Cingulum | ||||||||||
Tract volume | 195 | 61 | 0.04 | 0.28 | 0.02 | 0.48 | 0.04 | 0.35 | 0.04 | 0.44 |
FA | 0.55 | 0.059 | 0.26 | 0.003− | 0.15 | 0.03 | 0.32 | 0.003− | 0.17 | 0.04 |
MD | 0.75 | 0.053 | 0.09 | 0.11 | 0.08 | 0.12 | 0.05 | 0.27 | 0.04 | 0.14 |
Left Inferior Longitudinal Fasciculus | ||||||||||
Tract volume | 3,557 | 807 | 0.03 | 0.39 | 0.05 | 0.21 | 0.02 | 0.48 | 0.36 | 0.001+ |
FA | 0.47 | 0.026 | 0.17 | 0.02 | 0.35 | <0.001− | 0.19 | 0.03 | 0.22 | 0.013+ |
MD | 0.83 | 0.030 | 0.27 | 0.003+ | 0.28 | 0.002+ | 0.18 | 0.03 | 0.08 | 0.04 |
Right Inferior Longitudinal Fasciculus | ||||||||||
Tract volume | 3,846 | 987 | 0.02 | 0.49 | 0.02 | 0.46 | 0.01 | 0.58 | 0.29 | 0.004+ |
FA | 0.47 | 0.026 | 0.11 | 0.07 | 0.22 | 0.007− | 0.22 | 0.02 | 0.20 | 0.06 |
MD | 0.82 | 0.033 | 0.17 | 0.02 | 0.13 | 0.04 | 0.19 | 0.03 | 0.15 | 0.03 |
Corpus Callosum Genu | ||||||||||
Tract volume | 3,908 | 1183 | 0.54 | <0.001− | 0.04 | 0.30 | 0.53 | <0.001− | 0.01 | 0.35 |
FA | 0.52 | 0.025 | 0.26 | 0.003− | 0.24 | 0.006− | 0.45 | <0.001− | 0.38 | 0.004+ |
MD | 0.90 | 0.070 | 0.54 | <0.001+ | 0.04 | 0.31 | 0.51 | <0.001+ | −0.05 | 0.10 |
Corpus Callosum Anterior Body | ||||||||||
Tract volume | 2,563 | 715 | 0.40 | <0.001− | 0.03 | 0.34 | 0.45 | <0.001− | 0.16 | 0.009+ |
FA | 0.56 | 0.024 | 0.27 | 0.003− | 0.23 | 0.006− | 0.30 | 0.004− | 0.14 | 0.09 |
MD | 0.80 | 0.045 | 0.32 | 0.001+ | 0.02 | 0.46 | 0.21 | 0.02 | −0.14 | 0.51 |
Bold: significant correlation at 5% FDR (p = 0.013) in multiple linear regression using age as a covariate;
: positive correlation;
: negative correlation.