Figure 2.
Tissue dynamics and steady-state behavior of the rigid stem cell niche. Two cases are plotted: for Case 1, an initial perturbation to tissue morphology, and for Case 2, a spatial perturbation to the permeability of the basal lamina. Simulation details are listed in Section SIV in the Supporting Material. (A) Approximate steady-state cell and regulatory molecule distributions for case 2. (B) Stem cell niche size at an approximate steady state. (C) Variation in tissue size, Th, over time. (D) Mean tissue size over time.