Fig. 4.

Expression of TMPAP in the RVLM attenuates the progression of left ventricular (LV) remodelling in a rat model of heart failure secondary to myocardial infarction (MI). a Summary data illustrating the effect of TMPAP expression in the RVLM on LV systolic pressure (LVSP), LV end diastolic pressure (LVEDP), maximum rate of LV pressure increase (dP/dT _max) and noradrenaline concentration in blood plasma in rats with MI or sham-operated. Values are mean ± SEM except of noradrenaline data expressed as median and interquartile ranges. ^# P < 0.05 compared to values obtained in respective sham-operated animals. *P < 0.05 compared to values obtained in post-MI animals transduced to express EGFP in the RVLM. b In LV pressure–volume plots, ash denotes significant (P < 0.05) rightward shift of the LV pressure–volume relationship curve in post-MI animals transduced to express EGFP in the RVLM compared with the relationship curve in a respective sham-operated group. Asterisk indicates significant (P < 0.05) shift of the pressure–volume curve to smaller LV volumes in post-MI/TMPAP group compared with post-MI/EGFP group. Numbers in parentheses indicate sample sizes