Table 1.
Physiological parameters in animals with myocardial infarction-induced heart failure expressing either TMPAP or GFP in the rostral ventrolateral medulla
| Sham | Post-MI | |||
|---|---|---|---|---|
| EGFP (n = 8) | TMPAP (n = 8) | EGFP (n = 6) | TMPAP (n = 7) | |
| Infarct size (%) | 28.9 ± 3.4 | 27.3 ± 2.8 | ||
| Body weight (g) | 439 ± 16 | 422 ± 16 | 441 ± 14 | 432 ± 23 |
| Heart weight (g) | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.9 ± 0.3* | 1.9 ± 0.1* |
| LV weight (g) | 0.9 ± 0.1 | 0.9 ± 0.1 | 1.2 ± 0.1* | 1.2 ± 0.1* |
| Wet lungs weight (g) | 1.7 ± 0.1 | 1.8 ± 0.1 | 2.1 ± 0.3 | 2.0 ± 0.3 |
| Dry lungs weight (g) | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.4 ± 0.1 |
| Pulmonary water content (g) | 1.2 ± 0.3 | 1.3 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.2 |
| Mean arterial blood pressure under anaesthesia (mmHg) | 112 ± 3 | 113 ± 7 | 77 ± 5* | 83 ± 3* |
| Heart rate (bpm) | 355 ± 21 | 370 ± 13 | 343 ± 10 | 371 ± 15 |
Bpm beats per minute, EGFP enhanced green fluorescent protein (animals transduced to express EGFP in the rostral ventrolateral medulla oblongata), LV left ventricle, MI myocardial infarction, TMPAP transmembrane prostatic acid phosphatase (animals transduced to express TMPAP in the rostral ventraolateral medulla oblongata)
* P < 0.05 compared to values obtained in respective sham-operated animals