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. 2013 Jan 9;3:415. doi: 10.3389/fimmu.2012.00415

Figure 1.

Figure 1

Overview of protective properties of NAbs specific to OSEs. NAbs exhibit housekeeping and host defense functions by targeting OSEs on the surface of apoptotic cells, self antigens, and microbial agents. Insufficient NAbs titers may lead to impaired clearance of cellular debris and reduced protective capacity from invading pathogens. Accumulation of apoptotic material can trigger auto-immune responses and promote chronic inflammatory diseases.