Table 1.
Characteristics of Patients
| Fibulin-1 First Tertile (n=42) | Fibulin-1 Second Tertile (n=42) | Fibulin-1 Third Tertile (n=41) | P | |
|---|---|---|---|---|
| Age, y | 71±8 | 72±11 | 74±8 | 0.36 |
| Male sex | 34 (81) | 22 (52) | 23 (56) | 0.01 |
| Hypertension | 22 (52) | 15 (36) | 16 (39) | 0.26 |
| Arteriosclerosis | 21 (50) | 17 (40) | 19 (46) | 0.68 |
| Diabetes mellitus | 5 (12) | 6 (14) | 8 (20) | 0.62 |
| AF | 4 (5) | 5 (12) | 10 (24) | 0.13 |
| Ischemic heart disease | 9 (21) | 7 (17) | 7 (17) | 0.82 |
| Peripheral artery disease | 5 (12) | 2 (5) | 4 (10) | 0.50 |
| Stroke | 1 (2) | 3 (7) | 4 (10) | 0.38 |
| EuroSCORE | 5.3±1.9 | 5.9±1.8 | 6.1±2.1 | 0.13 |
| Logistic EuroSCORE | 4.6±3.1 | 5.6±3.3 | 6.3±5.3 | 0.16 |
| Diuretic therapy | 17 (40) | 11 (26) | 16 (39) | 0.32 |
| β-Blocker therapy | 8 (19) | 9 (21) | 11 (27) | 0.69 |
| CCB therapy | 11 (26) | 7 (17) | 7 (17) | 0.47 |
| Candesartan | 19 (45) | 21 (50) | 23 (56) | 0.61 |
| Symptoms | ||||
| 6-min walk test, m | 348±126 | 338±123 | 347±128 | 0.94 |
| NYHA functional class | 2.2±0.7 | 2.0±0.7 | 2.1±0.7 | 0.30 |
| NYHA functional class 1/2/3/4 | 6/20/16/0 | 9/24/9/0 | 8/21/11/1 | 0.52 |
| Creatinine, μmol/L | 98±21 | 97±19 | 105±24 | 0.22 |
| Plasma fibulin-1, μg/mL | 57±9 | 85±9 | 125±27 | |
Data are n (%) or mean±SD or n. AF indicates atrial fibrillation; CCB, calcium channel blocker; NYHA, New York Heart Association.