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. 2012 Dec 19;1(6):e002238. doi: 10.1161/JAHA.112.002238

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© 2012 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 12. — Diet-induced diabetes (DIDM) impaired recovery from hind-limb ischemia, induced adipocyte differentiation in ischemic muscle, and restricted MSC multipotency. A, Foot blood flow recovery in DIDM (mean±SEM, n=6; *P<0.05 vs DIDM; note that the WT data shown here were generated specifically for comparison with DIDM and are different from those displayed in Figure 3). B, Intramuscular adipocyte infiltration within ischemic hind-limb muscle from DIDM. C, Oxidant levels, as shown by DCF staining (n=7). D, MSCs from DIDM demonstrated increased differentiation to an adipocyte phenotype (n=8). E, MSCs from DIDM demonstrated reduced differentiation to an endothelial phenotype (n=7 to 8). (For C through E: mean±SEM; *P<0.05.) WT indicates wild-type; MSC indicates mesenchymal stem cell.