Table 4.
Ventricular Functional Metrics as Assessed by Echocardiography*
| Parameter | Time, d* | ||||
|---|---|---|---|---|---|
| 0 | 3 | 21 | 35 | 49 | |
| End‐diastolic volume* | |||||
| AdVEGF‐All6A+/GMT | 217±7 | 181±13 | 215±17 | 222±21 | 234±25 |
| AdNull/GMT | 206±8 | 147±18 | 239±12 | 208±16 | 231±23 |
| AdVEGF‐All6A+/GFP | 192±11 | 197±11 | 302±30 | 240±32 | 280±32 |
| AdNull/GFP | 207±13 | 193±19 | 262±17 | 265±32 | 252±26 |
| End‐systolic volume | |||||
| AdVEGF‐All6A+/GMT | 54±5 | 80±7 | 99±10 | 80±11 | 84±7 |
| AdNull/GMT | 51±2 | 65±5 | 112±10 | 81±10 | 105±14 |
| AdVEGF‐All6A+/GFP | 47±3 | 97±8 | 148±17 | 117±23 | 139±20 |
| AdNull/GFP | 54±4 | 95±11 | 123±11 | 131±23 | 134±18 |
| Fractional shortening | |||||
| AdVEGF‐All6A+/GMT | 45±2 | 30±2 | 29±1 | 36±2 | 35±1*** |
| AdNull/GMT | 45±1 | 29±2 | 28±1 | 34±2 | 30±1** |
| AdVEGF‐All6A+/GFP | 46±1 | 27±2 | 27±1 | 28±2 | 27±1* |
| AdNull/GFP | 44±1 | 27±1 | 28±2 | 27±2 | 25±1** |
*
All data expressed as a percentage ejection fraction (n=6 animals per treatment group). VEGF indicates vascular endothelial growth factor; GMT, Gata4, Mef2c, and Tbx5; MYH7, myosin heavy chain 7.
*
Day 0 represents time of coronary ligation and AdVEGF‐All6A or AdNull administration; day 21 represents time of administration of lentivirus encoding GMT or GFP.
*
No significant difference between groups at any time interval.
*
AdVEGF‐All6A+/GMT versus AdNull/GMT: P=0.08.
*
AdVEGF‐All6A+/GMT versus AdVEGF‐All6A+/GFP: P<0.01.
*
AdVEGF‐All6A+/GMT versus AdNull/GFP: P<0.0001.
*
AdNull/GMT versus AdNull/GFP: P=0.07.