Figure 8. Direct gradient analysis of human lung explant OTUs at high-resolution constrained by anatomic location.

The bacterial communities of COPD lung explants were binned at high-resolution, and constrained ordinations were constructed using the location in the lung from which the sample originated at the constraint. Ordinations were CAP ordinations based on (A) Bray-Curtis distance, or (B) Jaccard distance; (C) RDA; (D) CCA. Individual samples were colored based on the anatomic location in the lung from which they were obtained.