Table 4.
| a. Genes differentially expressed in two or more unselected FS0 strains relative to the New Orleans strain. Ratio of the average expression of each comparison is displayed on a linear scale. Probability value is shown as a negative log10 scale. | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Activity | Iquitos | Calderitas | Lázaro C | Solidaridad | Mérida | Lagunitas | |||||||
| Gene | Vector Base ID | Ratio | p | Ratio | p | Ratio | p | Ratio | p | Ratio | p | Ratio | p |
| Glutathione transferases | |||||||||||||
| AaGSTe3 | AAEL007947 | 2.06 | 4.29 | 1.99 | 9.80 | 2.93 | 10.98 | ||||||
| AaGSTe4 | AAEL007962 | 2.48 | 13.09 | 3.18 | 10.44 | ||||||||
| AaGSTe6 | AAEL007946 | 2.23 | 9.90 | 2.01 | 9.53 | 2.03 | 10.07 | 3.25 | 9.49 | ||||
| AaGSTs1-2 | AAEL011741 | 0.35 | 4.59 | 0.27 | 14.14 | ||||||||
| GSTd5 | AAEL001071 | 2.04 | 4.23 | 0.46 | 19.18 | ||||||||
| Cytochrome P450 monoxygenases | |||||||||||||
| CYP6Nae1 | AAEL009126 | 2.20 | 5.43 | 2.07 | 6.18 | ||||||||
| CYP6P12V2 | AAEL014891 | 0.37 | 6.82 | 0.45 | 11.83 | 0.48 | 6.99 | ||||||
| CYP6Z6_b | AAEL009123 | 2.08 | 7.32 | 2.25 | 18.07 | 2.22 | 6.27 | ||||||
| CYP9AE1 | AAEL003748 | 0.47 | 4.56 | 0.37 | 4.85 | ||||||||
| CYP9J10 v2 | AAEL014614 | 2.04 | 3.47 | 3.01 | 18.53 | ||||||||
| CYP9J22 v1 | AAEL006802 | 2.28 | 7.86 | 2.64 | 13.31 | 2.27 | 5.70 | ||||||
| CYP9J22 v2 | AAEL014619 | 2.39 | 7.72 | 2.66 | 13.54 | 2.39 | 3.62 | ||||||
| CYP9J23_b | AAEL014615 | 2.35 | 5.54 | 2.33 | 15.37 | ||||||||
| CYP9J28 | AAEL014617 | 3.14 | 6.80 | 2.93 | 15.98 | ||||||||
| CYP9J32 | AAEL008846 | 8.82 | 12.22 | 2.95 | 20.01 | ||||||||
| CYP9J9 v2 | AAEL014605 | 2.06 | 13.54 | 2.00 | 17.62 | ||||||||
| Red/Ox | |||||||||||||
| Peroxinectin 4390 | AAEL004390 | 2.03 | 7.28 | 3.23 | 8.61 | ||||||||
| b. Genes differentially expressed in one of the unselected FS0 strains relative to the susceptible New Orleans strain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Glutathione transferases | |||||||||
| AaGSTd1-1 | AAEL001061 | 4.00 | 11.45 | ||||||
| AaGSTd1-2 | AAEL001061 | 2.38 | 4.50 | ||||||
| AaGSTd1-3 | AAEL001061 | 2.48 | 8.64 | ||||||
| AaGSTe7 | AAEL007948 | 3.25 | 10.39 | ||||||
| AaGSTs1-1 | AAEL011741 | 1.39 | 10.70 | ||||||
| Cytochrome P450 monoxygenases | |||||||||
| CYP4G36 | AAEL004054 | 0.33 | 6.00 | ||||||
| CYP6BB2a | AAEL014893 | 4.66 | 4.77 | ||||||
| CYP6CB1 | AAEL002046 | 2.81 | 24.91 | ||||||
| CYP9J19 v1 | AAEL006810 | 2.57 | 14.59 | ||||||
| CYP9J9 v1 | AAEL006793 | 2.00 | 15.37 | ||||||
| Carboxyl/esterases | |||||||||
| AaeCOE-10 | AAEL001517 | 1.41 | 13.24 | ||||||
| AaeCOE-17 | AAEL004341 | 0.21 | 10.62 | ||||||
| CCae2B | AAEL017553 | 1.28 | 11.07 | ||||||
| CCae5C | AAEL003201 | 0.40 | 9.75 | ||||||
| CCEunk6o | AAEL000545 | 1.38 | 10.21 | ||||||
| Red/Ox | |||||||||
| Peroxinectin 3612 | AAEL003612 | 4.51 | 8.14 | ||||||
| Peroxinectin 4388 | AAEL004388 | 4.51 | 9.44 | ||||||
| Dihydrolipoamide dehydrogenase | AAEL006928 | 0.42 | 5.84 | ||||||
| Aldehyde oxidase 10367 | AAEL010367 | 2.30 | 10.57 | ||||||
| Glutaredoxin 13980 | AAEL013980 | 2.71 | 5.95 | ||||||
| Aldo-keto reductase 15002 | AAEL015002 | 4.08 | 4.85 | ||||||
| Catalase | AAEL013407 | 0.32 | 8.41 | ||||||
| Thioredoxin peroxidase 9051 | AAEL009051 | 2.14 | 3.70 | ||||||
| Others | |||||||||
| 40S ribosomal ptn S17 | AAEL004175 | 2.50 | 11.88 | ||||||
| 60S ribosomal ptn L44 L41 | AAEL003942 | 2.14 | 7.71 | ||||||