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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Pain. 2012 Sep 26;153(12):2422–2431. doi: 10.1016/j.pain.2012.08.011

Fig. 5.

Fig. 5

Ceftriaxone decreases spinal glutamate and prevents the facilitation of glutamate release by mGluR5 activation in rats 1 week after SNI. A, Glutamate uptake in the ipsilateral dorsal horn of rats after SNI that were treated with vehicle or ceftriaxone (N=5–6), not significant. B, Glutamate in the CSF of naïve rats compared to untreated rats after SNI, and rats after SNI that were treated with vehicle or ceftriaxone (N=12). ** p<0.01, one-way ANOVA followed by a Bonferroni test. C–D, Whole cell patch clamp recordings, performed on acute slices of the spinal cord. C, mEPSC frequency and amplitude of rats treated with vehicle (N=7 neurons) or ceftriaxone (N=16 neurons). *p<0.05 D, Effect of MPEP (10 μM) on mEPSC frequency and amplitude in rats treated with ceftriaxone (N=4).