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. 2012 Nov 23;3(1):2041731412467789. doi: 10.1177/2041731412467789

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© The Author(s) 2012

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Figure 4. — Comparative overview on gene expression of OPN and RUNX-2 (N = 6 replicates per time point). (a) OPN gene expression was significantly upregulated by BAG in BMP-2/7 medium as compared to β-TCP. Furthermore, BMP-2/7 induced significantly higher OPN expression as compared to BMP-2 in BAG group, suggesting a permissive effect on early osteogenesis. (b) RUNX-2 gene expression was significantly upregulated by β-TCP in OM as compared to BAG. However, additional BMP supplementation failed to enhance the expression. These findings were in alignment with ALP staining.

OPN: osteopontin; RUNX-2: runt-related transcription factor 2; BAG: bioactive glass; CM: control medium; OM: osteogenic medium; BMP: bone morphogenetic protein; β-TCP: beta-tricalcium phosphate; ALP: alkaline phosphatase; TM: treatment media.

The symbol “*” indicates significant difference between biomaterials; “a” indicates significant different as compared to CM; “b” indicates significant different as compared to OM.