Figure 5.

Comparative overview on gene expression of Col-1 and OC (N = 6 replicates per time point). (a) Our data revealed significantly lower marker expression for Col-1 in all TMs in the BAG group as compared to CM and was in accordance with ALP stainings. However, β-TCP downregulated Col-1 expression in BMP-7 and BMP-2/7 media only as compared to CM. (b) The gene expression for OC was neither different between biomaterials nor among media evaluated.

Col-1: collagen type-1; OC: osteocalcin; CM: control medium; ALP: alkaline phosphatase; β-TCP: beta-tricalcium phosphate; OM: osteogenic medium; BMP: bone morphogenetic protein; TM: treatment media.

“a” indicates significant different as compared to CM.