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. 2012 Aug;53(8):1472–1481. doi: 10.1194/jlr.M023234

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Fig. 1. — Inflammatory response to LPS following bone marrow transplantation. Bone marrow cells from male SR-BI^+/+ or SR-BI^−/− mice were transfused into irradiated male (A) SR-BI^+/+ and (B) SR-BI^−/− mice through tail-vein injection. After 4 weeks of recovery on antibiotics, recipient SR-BI^−/− and SR-BI^+/+ mice were injected intraperitoneally with 0.25 μg/g body weight (A) or 0.1 μg/g body weight (B) of LPS. Mice were euthanized after 2 h. Plasma cytokine levels were determined by ELISA. (C) Plasma corticosterone levels were determined by RIA kits. Values shown are the mean ± SD, n = 5 mice/group. (D) Bone marrow cell DNA was analyzed for the presence of SR-BI^+/+ and SR-BI^−/− alleles by PCR. (Top panel) Lanes 1–4 and 9–12 SR-BI ^−/− mice receiving SR-BI ^+/+ bone marrow cells; lanes 5–8 and 13–16 SR-BI ^−/− mice receiving SR-BI^−/− cells. (Bottom panel) Lanes 1,2,3,4, 9,10,11,12 SR-BI^+/+ mice receiving SR-BI ^−/− bone marrow cells; lanes 5–8 and 13–16 SR-BI ^+/+ mice receiving SR-BI ^+/+ cells. (Upper band) Gene product from SR-BI ^−/− genotype. (Lower band) Gene product in SR-BI ^+/+ genotype. *P < 0.05, WT versus SR-BI KO.