TABLE 1.

Plasma concentrations of HUFAs and their oxylipin products (mean ± SEM) before and after 4 weeks of 4 g/day n3 FA ethyl esters

	Pre	Post	Fold Change	P*
Parent fatty acid (µM)
ΣHUFAs	1,680 ± 150	2,370 ± 290	<+2	0.04
20:4n6	1,240 ± 99	1,140 ± 140	—	>0.05
22:4n6	41.9 ± 3.0	23.9 ± 2.9	−2	<0.001
22:5n6	33.6 ± 3.2	15.3 ± 1.9	−2	<0.001
20:5n3	74.5 ± 17	512 ± 69	+7	<0.001
22:5n3	73 ± 10	130 ± 20	+2	<0.01
22:6n3	222 ± 26	557 ± 66	+3	<0.001
Oxylipin (nM)
ΣHUFA alcohols (n = 10)	789 ± 92	756 ± 47	—	>0.05
20:4n6 alcohols (n = 6)	732 ± 87	562 ± 87	<−2	>0.05
20:5n3 alcohols (n = 3)	17.7 ± 3.2	101 ± 8.0	+6	<0.0001
22:6n3 alcohols (n = 1)	39.3 ± 3.7	94.0 ± 7.1	+2	<0.0001
ΣHUFA epoxides (n = 10)	58.9 ± 14	65 ± 13	—	>0.05
20:4n6 epoxides (n = 3)	50.6 ± 11.37	40.6 ± 7.86	—	>0.05
20:5n3 epoxides (n = 2)	1.13 ± 0.37	9.12 ± 2.03	+9	<0.001
22:6n3 epoxides (n = 2)	7.13 ± 2.02	15.4 ± 3.29	+2	0.07
ΣHUFA vic-diols (n = 10)	62.9 ± 4.0	68.5 ± 5.5	—	>0.05
20:4n6 diols (n = 3)	23.8 ± 2.0	20.0 ± 1.5	—	0.13
20:5n3 diols (n = 2)	38.0 ± 2.6	47.3 ± 4.1	<+2	0.09
22:6n3 diols (n = 1)	0.48 ± 0.3	1.17 ± 0.20	+2	<0.001

* Differences in means were assessed by paired two-tailed t-tests.