TABLE 2.

Changes in plasma lipids, lipoproteins, Lp-PLA₂, and OxPL on lipoproteins and hsCRP pre- and postapheresis

	Low Lp(a) Group (n = 6)			Intermediate Lp(a) Group (n = 6)			High Lp(a) Group (n = 6)
	Pre	Post	P	Pre	Post	P	Pre	Post	P
Total cholesterol, mg/dl	269 ± 64	88 ± 27	<0.001	312 ± 110	100 ± 26	<0.005	243 ± 28	94 ± 20	<0.001
Triglyceride, mg/dl	77 ± 36	24 ± 14	<0.005	101 ± 45	65 ± 75	0.12	159 ± 79	95 ± 44	0.07
HDL-C, mg/dl	39 ± 12	33 ± 12	<0.05	37 ± 9	31 ± 8	<0.001	40 ± 12	34 ± 11	<0.001
LDL-C, mg/dl	215 ± 66	50 ± 32	<0.001	255 ± 112	57 ± 27	<0.005	171 ± 23	41 ± 27	<0.001
ApoA-I, mg/dl	113 ± 32	97 ± 31	<0.001	108 ± 16	90 ± 11	<0.005	122 ± 30	101 ± 21	<0.01
ApoB, mg/dl	135 ± 28	34 ± 15	<0.001	167 ± 61	42 ± 14	<0.005	133 ± 9	39 ± 15	<0.0001
Lp(a), mg/dl	10 ± 0.4 (range,  10–11)	10 ± 0.0 (range,  10–10	0.36	42 ± 11 (range,  30–61)	12 ± 2.5 (range,  10–15	<0.001	103 ± 20 (range,  78–158	28 ± 11 (range,  17–48)	<0.0005
hsCRP, g/dl	0.06 ± 0.08	0.02 ± 0.02	0.23	0.14 ± 0.26	0.04 ± 0.08	0.25	0.07 ± 0.08	0.05 ± 0.07	<0.05
Lp-PLA2 mass, ng/ml	235 ± 37	114 ± 32	<0.001	294 ± 41	160 ± 29	<0.001	274 ± 71	137 ± 56	0.004
Lp-PLA2 activity, mmol/ml/min	189 ± 41	69 ± 32	<0.001	215 ± 44	89 ± 24	<0.001	179 ± 61	78 ± 56	0.014
sPLA2 mass, ng/ml	5.0 ± 2.5	4.2 ± 2.3	0.11	2.5 ± 1.1	1.7 ± 0.4	0.23	4.4 ± 1.9	3.0 ± 2.3	0.004
sPLA2 activity, mmol/ml/min	62.2 ± 23.0	65.0 ± 16.0	0.50	45.1 ± 7.1	60.4 ± 13.1	0.16	62.0 ± 6.8	62.4 ± 13.1	0.91
OxPL/apoB, RLU	1821 ± 871	2432 ± 1471	0.40	5247 ± 2807	2731 ± 1354	0.076	16723 ± 4718	6462 ± 1673	<0.001
OxPL/apo(a), RLU	4314 ± 1455	1541 ± 930	0.003	23110 ± 11277	4791 ± 1887	0.003	41686 ± 11422	14944 ± 3830	<0.001
OxPL/apoA-I, RLU	103 ± 92	87 ± 120	0.80	441 ± 192	313 ± 202	0.29	486 ± 90	386 ± 165	0.22