TABLE 1.
Physiological characteristics and serum chemistry
| Control |
CA-Fed |
|||
| Wild-type mice | Ppara-null mice | Wild-type mice | Ppara-null mice | |
| Body mass (%) | 100 ± 10.2 | 104 ± 1.7 | 91.1 ± 6.1 | 67 ± 0.5a |
| Liver/body mass (%) | 3.2 ± 0.1 | 3.6 ± 0.2 | 3.6 ± 0.2 | 6.1 ± 0.7a |
| ALT (U/l) | 28.5 ± 4.4 | 29 ± 8.7 | 335 ± 148 | 3660 ± 389a |
| ALP (U/l) | 104 ± 29.2 | 65 ± 12.4 | 67 ± 6.8 | 396 ± 63.3a |
| Glucose (mg/dl) | 198 ± 29 | 150 ± 46.4 | 157 ± 16.2 | 85 ± 8.4a |
| Total bilirubin (mg/dl) | 0.4 ± 0 | 0.4 ± 0 | 0.4 ± 0.1 | 0.7 ± 0.1b |
| BUN (mg/dl) | 18 ± 3.6 | 21 ± 3.8 | 20.5 ± 3.4 | 30 ± 3.3a |
| Potassium (mmol/l) | 7.1 ± 0.5 | 7.7 ± 0.6 | 7.2 ± 0.5 | 10.9 ± 0.6a |
| Total protein (g/dl) | 6 ± 0.7 | 5.6 ± 0.1 | 5.6 ± 0.3 | 4.9 ± 0.2b |
Comparison of diagnostic biomarkers between wild-type and Ppara-null mice fed with CA diet (n = 4). The percentage of body weight was calculated by comparing the body weight at day 12 to the starting weight at day 0. The liver/body mass was calculated by comparing the liver weight at day 12 to the body weight at day 12.
a
P< 0.01.
b
P< 0.05.