Figure 1.

Molecular signal transduction pathways for c-MET and RET, with targets of therapeutic agents. VEGFR2 on adjacent endothelial cell showing mechanism of angiogenic signaling.

Note: Dashed arrow represents molecular signal tranduction pathways.

Abbreviations: PI3K, phosphoinositol-3-kinases; FAK, focal adhesion kinase; HIF1α, hypoxia-induced factor 1 alpha; mTOR, mammalian target of rapamycin; GDNF, glial-cell-line-derived neurotrophic factor; HGF, hepatocyte growth factor; VEGFR2, vascular endothelial growth factor receptor 2.