Figure 4.

Cytokine production in spleen and tumor after treatment with vvDD or vvCCL19. Mice (C57/BL6 bearing subcutaneous MC38 tumors, n = 5 per group) were treated systemically (IP) with 1 x 10⁸ PFU of the indicated viruses. Mice were sacrificed after 4 and 8 days, and tumor and spleens were recovered for analysis of cytokine production by Luminex assay. Many cytokines are increased in the tumor after vvCCL19 production (relative to vvDD) at day 4, whereas there is little difference in the tumor until day 8.