Figure 6.

In vivo dynamic PET imaging of selective targeting and uptake of unencapsulated and nanoformulated ¹⁸F-SKI249380 in mGBM. (A) Representative axial microPET images at 1 hour p.i., demonstrating uptake of unencapsulated ¹⁸F-SKI249380 and micelleor liposome-formulated ¹⁸F-SKI249380 in tumor-bearing brains (arrows) as against non-tumor-bearing (control) brain (arrowhead). (B) Graphical summary of tumor uptake values (%ID/g) for treatment and control groups. (C) Representative sagittal microPET brain images from control and tumor-bearing (arrows) animals i.v. injected with ¹⁸F-SKI249380, the latter before (pre-block) and after (post-block) blocking with pharmacologic doses of dasatinib. Corresponding 1-hour TACs are shown. Each bar represents mean ± SD. One-tailed Mann-Whitney U tests demonstrated statistical significance at the P ≤ .05 level for micelles (*P = .002) and liposomes (**P = .014) relative to controls, as well as between micelles and liposomes (***P = .016).