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. 2012 Dec;14(12):1164–1177. doi: 10.1593/neo.121088

Figure 7.

Figure 7

Loss of E-cadherin expression in conducting airway epithelium leads to bronchiolar hyperplasia. (A) Histologic analysis through H&E staining of lungs from control and 2-week DOX-treated DTR mice showing the presence of epithelial hyperplasia (arrow). (B) Quantitation of bronchiolar hyperplasia between the mice groups: wt, wild type (n = 13), (C) Scgb1a1-rtTA (n = 27), (D) Tet-O dn E-cadherin (n = 23), DTR OFF DOX (n = 39), DTR ON DOX (n = 40); *P < .05. (C) Double immunofluorescence staining of the same lung sections from A for indicated markers. Asterisk shows a PGP 9.5-positive NEB region. Marked region shows an expansion of an NEB region consisting of PGP 9.5-and Scgb1a1-positive cells after induction. Nuclei were counterstained with DAPI (blue). (D) Immunohistochemical staining of lung sections for Scgb1a1. Images are representative of n = 6 mice in each group. Hematoxylin (blue) was used as a counterstain.