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pRB activates NOL7 transcription by recruiting SP1, co-activators, and chromatin remodeling proteins to its promoter. (A and B) SAPA analysis was performed on cells expressing control (SCR) or RB-specific shRNA to assess the enrichment of proteins on the NOL7 promoter on RB loss. Each SAPA experiment was repeated twice. A representative Western image depicting NOL7 promoter-enriched proteins in control or pRB knockdown cells is shown here.
