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. 2012 Dec 25;2012:686972. doi: 10.1155/2012/686972

Figure 4.

Figure 4

Mitochondrial and NADPH-dependent ROS production does not differ between mutant and wild-type mice. Results are expressed as a percentage of the respective control values in the absence of inhibitor. (a) and (b) Antimycin, 50 μM, inhibited mitochondrial ROS production to the same level in tissues of both Eng +/−, Alk1 +/− and respective wild-type mice. N = 5–11/group for Eng mice and 5–15/group for Alk1 mice, except for liver samples from Alk1 +/+ mice, where N = 4. (c) and (d) Apocynin, 100 μM, inhibited NADPH-oxidase dependent H2O2 production in tissues of both mutant and wild-type mice. N = 5–8/group for both Eng and Alk1 mice, except for heart samples from both groups of mice, where N = 4. *P < 0.05, **P < 0.01, ***P < 0.001, and † P < 0.1 versus corresponding control values (samples without inhibitor).