Table 1.

Diameter, polydispersity index, zeta potential, and encapsulation efficiency of different nanoparticles

	Diameter (nm)1	Polydispersity index	Zeta potential (mV)	Encapsulation efficiency (% zoledronic acid)
LCP-poly (I:C)	184 ± 25	0.22 ± 0.02	43.2 ± 5.3	N/A
Lipoplex-poly (I:C)-zoledronic acid2	138 ± 40	0.33 ± 0.30	44.2 ± 6.3	42 ± 5.7
CaP-poly (I:C)-zoledronic acid2	359 ± 15	0.12 ± 0.10	−10.1 ± 2.5	90 ± 2.4
LCP-poly (I:C)-zoledronic acid2	205 ± 20	0.17 ± 0.04	21.7 ± 4.2	94 ± 1.3

Notes: Data are presented as the mean ± standard deviation; poly (I:C)-zoledronic acid = 1:1 (weight ratio).

Abbreviations: CaP, calcium phosphate; LCP, lipid-coated calcium phosphate nanoparticles; poly (I:C), polyinosinic acid-polycytidylic acid.