Table 2.

Differential expression of miRNAs, miRNA cistronic clusters and miRNA sequence families at false detection rate < 0.1 (differential expression of miRNAs at nominal P-value < 0.05 are presented in Table S6) in discovery cohort biopsies

miRNA, miRNA cistronic cluster or miRNA sequence family	Normalized miRNA read frequency		Fold change	FDR
	Normal (n=4)	IFTA (n=3)
Merged miRNA
miR-21	3.6%	8.4%	2.3	0.006
miR-142-3pa	0.068%	0.18%	2.6	0.012
miR-514a(3)	0.0044%	0.023%	5.3	<0.0001
miR-21*	0.0026%	0.010%	3.9	0.012
miR-508	0.0011%	0.0095%	8.4	<0.0001
miR-509-3p(3)	0.0007%	0.0070%	9.4	<0.0001
miR-506	0.0002%	0.0015%	7.1	0.074
miR-514a*(3)	0.0002%	0.0042%	24	<0.0001
miR-509-5p(2)	0	0.0013%	inf.	0.006
miRNA cistronic clusters
cluster-mir-21(1)	3.4%	8.2%	2.4	0.006
cluster-mir-142(1)	0.087%	0.21%	2.4	0.077
cluster-mir-506(11)	0.0065%	0.044%	6.7	<0.0001
miRNA sequence families
sf-miR-21(1)	3.4%	8.1%	2.4	0.008
sf-miR-142-3p(1)	0.064%	0.17%	2.6	0.026
sf-miR-514a-1(4)	0.0044%	0.022%	5.1	<0.0001
sf-miR-21*(1)	0.0024%	0.0093%	3.8	0.010
sf-miR-508(1)	0.0010%	0.0088%	8.4	<0.0001
sf-miR-509-1-3p(3)	0.0006%	0.0060%	9.9	<0.0001
sf-miR-509-1-5p(3)	0.0003%	0.0018%	7.0	0.026
sf-miR-506(1)	0.0002%	0.0015%	6.9	0.085
sf-miR-514a-1*(3)	0	0.0035%	inf.	<0.0001

^amiR-142-5p was also higher in IFTA biopsy samples, see Table S6.