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. Author manuscript; available in PMC: 2013 Jan 9.
Published in final edited form as: ChemMedChem. 2009 Feb;4(2):241–248. doi: 10.1002/cmdc.200800261

Table 3.

In vitro activities of select triclosan derivatives against M. tuberculosis InhA.[a]

graphic file with name nihms415568t2.jpg
Cmpd R1 R2 InhA IC50
(nM)
8 CH2CH3 Cl 120 ± 19
9 (CH2)2CH3 Cl 91 ± 15
10 (CH2)3CH3 Cl 55 ± 20
11 CH2CH(CH3)2 Cl 96 ± 46
12 (CH2)2CH(CH3)2 Cl 63 ± 9
13 CH2CH(CH3)CH2CH3 Cl 130 ± 56
14 2-pyridyl CN >10000
15 3-pyridyl Cl >10000
16 4-pyridyl CN >10000
17 CH2(2-pyridyl) Cl 29 ± 11
18 CH2(3-pyridyl) Cl 42 ± 10
19 CH2(4-pyridyl) CN 75 ± 16
20 o-CH3-Ph Cl 1300 ± 77
21 o-CH3-Ph CN >10000
22 m-CH3-Ph Cl 870 ± 110
23 p-F-Ph Cl >10000
24 CH2Ph Cl 51 ± 6
25 (CH2)2Ph Cl 21 ± 8
26 (CH2)3Ph Cl 50 ± 14
[a]

Values reported as the mean ± standard error for at least three independent measurements.