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. Author manuscript; available in PMC: 2013 Jan 9.
Published in final edited form as: ChemMedChem. 2009 Feb;4(2):241–248. doi: 10.1002/cmdc.200800261

Table 4.

Activities of triclosan derivatives against wild-type and mutant M. tuberculosis strains.

Cmpd MIC H37Rv
(µg/ml) (µM)		 MIC
H37Rv inhA
(S94A)
(µg/ml) (µM)		 MIC
H37Rv PmabAinhA (C-15T)
(µg/ml) (µM)		 MIC
H37Rv ΔkatG
(µg/ml) (µM)		 MIC
clinical isolate 12081
(µg/ml) (µM)		 MIC
clinical isolate 5071
(µg/ml) (µM)
INH 0.060 (0.44) 0.50 (3.6) 0.80
(5.8)		 >200 (>1400) 1.0
(7.3)		 8.0
(56)
triclosan 40 (140)
7 9.4
(27)		 37 (110) 37
(110)		 19
(55)		 37
(110)		 4.7
(13)
10 9.4
(30)		 37 (120) 37
(120)		 19
(60)		 37
(120)		 4.7
(15)
11 19
(60)		 37 (120) 37
(120)		 37
(120)		 75
(240)		 19
(60)
24 9.4
(27)		 75 (220) 37
(110)		 19
(55)		 75
(220)		 9.4
(27)
25 19
(52)		 75 (210) 75
(210)		 37
(110)		 75
(210)		 19
(52)
26 4.7
(13)		 19
(50)		 19
(50)		 9.4
(26)		 37
(100)		 4.7
(13)