Table 3.
Gender Differences in ECM Enzyme Expression1 in MPSI Mice
| MMP9 | MMP12 | |||
|---|---|---|---|---|
| Apex (N) | Aorta (N) | Apex (N) | Aorta (N) | |
| Males | 6.7±2.8 (9)* | 5.4±2.5 (7)* | 13.4±9.2 (10)† | 74.5±56.6 (9)† |
| AI+ | 6.6±3 (8)** | 4.6±1.5 (6)** | 12.7±5.8 (8)†† | 73.4±60.4 (8)††† |
| Females | 5.9±2.4 (6) | 4.5±3.2 (6) | 7.8±5.8 (6) | 36.4±19.7 (6) |
| AI+ | 5.2±0.5 (3) | 3.6±1.2 (3) | 6.5±3 (3)** | 5.7±2.6 (3) |
*
p-value >0.05 MMP9 in apex or aorta of MPSI males vs MPSI females
**
p-value >0.05 MMP9 in apex or aorta of MPSI males AI+ vs. MPSI females AI+
†
p-value >0.05 MMP12 in apex, and >0.05 in aorta of MPSI males vs MPSI females
††
p-value >0.05 MMP12 in apex of MPSI males AI+ vs MPSI females AI+
†††
p-value = 0.0242 MMP12 in aorta of MPSI males AI+ vs MPSI females AI+ For both MMP9 and MMP 12: p-value < 0.05 WT mice vs. any mutant group.
1
Normalized to expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Fold difference in comparison to wild-type mRNA expression is shown.
AI, aortic insufficiency; WT, wild type.