Table 3.

Genetic epistasis analyses

	cln3Δ	whi5Δ
mrpl49Δ	↑	●
yjr114wΔ	+	●
rpl36bΔ	+	●
rpl42aΔ	+	-
cbs1Δ	↑	●
rom2Δ	+	●
rpl16bΔ	NA	NA
ecm9Δ	●	↑
ctr9Δ	●	+

Genetic epistasis analysis with cln3Δ and whi5Δ. Double deletion combinations were created for the new logarithmic phase size mutants with cln3Δ (uge mutant) and whi5Δ (whi mutant). Haploids were analyzed for the cell size phenotype. Table represents the pair wise genetic relationships: Intermediate (+), epistatic (↑) (the gene pointed to by the arrow masked the size phenotype of the other deletion), synergistic (•), no effect (−). Epistasis was operationally defined as an average cell size for double mutants within +/− 5% of size of either single mutant. Synergistic effects refer to combinatorial cell sizes that are either substantially larger or smaller than each single mutant. Intermediate refers to combinatorial cell sizes that lie between the size of each single mutant. Since RPL16B is an essential gene, it could not be analyzed in these studies. Size values with statistics can be found in Additional file 1: Table S1.