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. 2012 Aug 21;7:110. doi: 10.1186/1746-1596-7-110

Table 5.

Diagnoses provided by evaluating pathologists and GEP test vs. the reference diagnosis

Case No. Reference Diagnosis Sex GEP
EP1
EP2
EP3
EP4
EP5
EP Overall, for 50 case reviews
Result Highest SS H&E Int Final All H&E Int Final All H&E Int Final All H&E Int Final All H&E Int Final All H&E Int All
Case 1
OV
F
OV
97.6
BR
OV
OV
OV
OV
OV
 
OV
OV
OV
 
OV
OV
OV
 
OV
OV
OV
OV
OV
--
--
--
Case 2
CO
M
CO
89.9
CO
CO
 
CO
CO
CO
 
CO
CO
CO
 
CO
PA
PA
 
PA
CO
LU
LU
LU
--
--
--
Case 3
CO
M
CO
87.6
CO
CO
 
CO
CO
CO
 
CO
CO
CO
 
CO
LU
CO
 
CO
CO
CO
CO
CO
--
--
--
Case 4
BR
F
BR
97.6
LU
OV
OV
OV
LU
LU
 
LU
BR
BR
PA
PA
OV
OV
PA
PA
OV
OV
OV
OV
--
--
--
Case 5
KI
M
KI
86.4
KI
KI
 
KI
KI
KI
 
KI
KI
KI
 
KI
LU
KI
 
KI
KI
KI
KI
KI
--
--
--
Case 6
ME
F
ME
67.4
LY
ME
ME
ME
BR
BR
 
BR
LI
ME
ME
ME
BR
ME
ME
ME
LU
ME
ME
ME
--
--
--
Case 7
BL
M
BL
45.1
GC
PA
BL
 
LU
GA
 
GA
LU
LU
BL
BL
LU
BL
 
BL
BR
BL
PA
PA
--
--
--
Case 8
SC
M
SC
76.1
SC
SC
 
SC
LI
SC
 
SC
SC
SC
SC
SC
LI
ME
 
ME
KI
LI
LI
LI
--
--
--
Case 9
GA
M
GA
36.9
GA
GA
 
GA
SC
GA
GA
GA
GA
GA
GA
GA
PA
PA
 
PA
LY
GA
GA
GA
--
--
--
Case 10
LU
M
OV
24.4
BL
BL
 
BL
BL
BL
 
BL
BL
BL
BL
BL
BL
BL
 
BL
BL
BL
BL
BL
--
--
--
No. incorrect
 
 
1
 
5
3
 
2
6
4
 
4
3
2
 
2
9
5
 
5
6
4
5
5
29
19
18
No. correct
 
 
9
 
5
7
 
8
4
6
 
6
7
8
 
8
1
5
 
5
4
6
5
5
21
31
32
% correct     90%   50% 70%   80% 40% 60%   60% 70% 80%   80% 10% 50%   50% 40% 60% 50% 50% 42% 62% 64%

The tumor tissue is indicated by a two-letter code: bladder (BL), breast (BR), colorectal (CO), gastric (GA), testicular germ cell (GC), kidney (KI), hepatocellular (LI), non-small cell lung (LU), non-Hodgkin’s lymphoma (LY), melanoma (ME), ovarian (OV), pancreas (PA), prostate (PR), thyroid (TH) and sarcoma (SC). SS – Similarity Score, a measure of the similarity of the RNA expression pattern of the specimen to the RNA expression pattern of the indicated tissue. Similarity Scores range from 0 (very low similarity) to 100 (very high similarity) and sum to 100 across all 15 tissues on the GEP Test panel. The incorrect predictions are indicated with yellow highlight. Grey indicates no stains ordered.