Table 5.
Pairwise Pearson correlation between circulating cytokine and chemokine levels in rhesus macaquesa
| IFN-γ | IL-1β | IL-6 | IL-12/ 23 (p40) | IL-15 | TNF-α | MCP-1 | MIP-1α | IL-1ra | IL-4 | MIP-1β | IL-17 | MIF | Eotaxin | IL-8 | I-TAC | MDC | MIG | RANTES | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
IFN-γ |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
IL-1β |
0.406 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
IL-6 |
0.725 |
0.425 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
IL-12/23(p40) |
0.408 |
0.763 |
0.341 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
IL-15 |
0.476 |
0.853 |
0.434 |
0.768 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
TNF-α |
0.668 |
0.470 |
0.438 |
0.534 |
0.527 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
MCP-1 |
0.276 |
0.637 |
0.332 |
0.466 |
0.561 |
0.286 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
MIP-1α |
0.689 |
0.788 |
0.664 |
0.712 |
0.779 |
0.582 |
0.507 |
|
|
|
|
|
|
|
|
|
|
|
|
|
IL-1ra |
0.377 |
0.855 |
0.376 |
0.893 |
0.843 |
0.509 |
0.597 |
0.772 |
|
|
|
|
|
|
|
|
|
|
|
|
IL-4 |
0.320 |
0.932 |
0.395 |
0.814 |
0.828 |
0.441 |
0.626 |
0.771 |
0.927 |
|
|
|
|
|
|
|
|
|
|
|
MIP-1β |
0.723 |
0.449 |
0.565 |
0.374 |
0.445 |
0.184 |
0.262 |
0.690 |
0.355 |
0.351 |
|
|
|
|
|
|
|
|
|
|
IL-17 |
0.075 |
0.174 |
−0.003 |
0.575 |
0.317 |
0.155 |
0.132 |
0.306 |
0.475 |
0.226 |
0.166 |
|
|
|
|
|
|
|
|
|
MIF |
−0.086 |
0.263 |
−0.221 |
0.008 |
0.054 |
0.096 |
−0.063 |
−0.013 |
0.177 |
0.456 |
−0.092 |
0.015 |
|
|
|
|
|
|
|
|
Eotaxin |
0.344 |
0.933 |
0.113 |
−0.271 |
0.298 |
0.239 |
0.672 |
0.366 |
−0.170 |
−0.202 |
0.278 |
−0.155 |
0.163 |
|
|
|
|
|
|
|
IL-8 |
−0.112 |
−0.355 |
−0.094 |
−0.285 |
−0.317 |
−0.085 |
−0.029 |
−0.331 |
−0.308 |
−0.329 |
−0.303 |
−0.115 |
0.513 |
−0.125 |
|
|
|
|
|
|
I-TAC |
0.443 |
0.222 |
0.425 |
−0.143 |
0.518 |
0.070 |
0.397 |
0.473 |
0.241 |
−0.233 |
0.356 |
0.148 |
0.094 |
0.393 |
−0.070 |
|
|
|
|
|
MDC |
−0.102 |
−0.160 |
−0.245 |
−0.034 |
−0.108 |
−0.125 |
−0.171 |
−0.171 |
0.086 |
0.142 |
−0.071 |
−0.126 |
−0.029 |
−0.211 |
0.024 |
−0.137 |
|
|
|
|
MIG |
0.039 |
0.191 |
−0.128 |
0.349 |
0.097 |
0.376 |
0.079 |
−0.006 |
−0.259 |
−0.376 |
0.023 |
0.138 |
−0.186 |
0.187 |
−0.263 |
0.121 |
0.023 |
|
|
| RANTES | −0.065 | −0.162 | −0.237 | 0.730 | 0.148 | 0.415 | −0.085 | 0.137 | 0.547 | 0.271 | 0.004 | 0.613 | 0.225 | −0.210 | 0.041 | −0.181 | −0.009 | −0.020 |
a Pairwise Pearson correlation coefficients (r values) were measured among cytokines and chemokines using GraphPad Prism software. Statistically significant (P < 0.05) correlation coefficients are designated in bold text. The inner box designates concordant correlation coefficients that were significant for each pair of inflammatory cytokines and chemokines tested within the group and the outer box also includes the two anti-inflammatory cytokines with significant correlation coefficients between each pairwise evaluation.