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. 2013 Jan 9;8(1):e53665. doi: 10.1371/journal.pone.0053665

Table 6. Haplotype analysis of ARMS2 and HTRA1 polymorphisms in exudative AMD and PCV.

No. SNPs Haplotype Frequency AMD-Control PCV-Control AMD-PCV
included AMD PCV Control p OR(95%CI) p OR(95%CI) p OR(95%CI)
1. rs10490924 G1 0.287 0.337 0.742 8.89×10−19 0.140 1.81 ×10−14 0.177 0.3093 0.792
EU 427528 (0.089–2.20) (0.112–0.280) (0.504–1.243)
(310–311) T2 0.697 0.657 0.247 2.08×10−18 6.993 8.24×10−15 5.818 0.4194 1.202
(4.445–11.001) (3.674–9.213) (0.769–1.878)
2. rs 10490924 TA 0.697 0.614 0.244 1.92×10−18 6.953 2.37×10−12 4.691 0.1038 1.452
(4.436–10.904) (3.015–7.299) (0.946–2.227)
rs 11200638 GG 0.269 0.298 0.544 2.47×10−8 0.300 1.57×10−6 0.361 0.4941 0.871
(0.195–0.460) (0.236–0.552) (0.556–1.346)
3. rs 11200638 ACC 0.720 0.651 0.452 1.42×10−7 3.129 1.0×10−4 2.277 0.1557 1.374
(2.033–4.816) (1.498–3.461) (0.884–2.136)
rs 55928386 GCC 0.134 0.142 0.269 9.0×10−4 0.422 0.0019 0.436 0.842 0.944
rs 2672598 (0.248–0.719) (0.258–0.737) (0.522–1.704)
*

For the polymorphisms that were not a single nucleotide change, the wild type was denoted as 1 and the variant denoted as 2.