Table 6. Haplotype analysis of ARMS2 and HTRA1 polymorphisms in exudative AMD and PCV.
No. | SNPs | Haplotype | Frequency | AMD-Control | PCV-Control | AMD-PCV | |||||
included | AMD | PCV | Control | p | OR(95%CI) | p | OR(95%CI) | p | OR(95%CI) | ||
1. | rs10490924 | G1 | 0.287 | 0.337 | 0.742 | 8.89×10−19 | 0.140 | 1.81 ×10−14 | 0.177 | 0.3093 | 0.792 |
EU 427528 | (0.089–2.20) | (0.112–0.280) | (0.504–1.243) | ||||||||
(310–311) | T2 | 0.697 | 0.657 | 0.247 | 2.08×10−18 | 6.993 | 8.24×10−15 | 5.818 | 0.4194 | 1.202 | |
(4.445–11.001) | (3.674–9.213) | (0.769–1.878) | |||||||||
2. | rs 10490924 | TA | 0.697 | 0.614 | 0.244 | 1.92×10−18 | 6.953 | 2.37×10−12 | 4.691 | 0.1038 | 1.452 |
(4.436–10.904) | (3.015–7.299) | (0.946–2.227) | |||||||||
rs 11200638 | GG | 0.269 | 0.298 | 0.544 | 2.47×10−8 | 0.300 | 1.57×10−6 | 0.361 | 0.4941 | 0.871 | |
(0.195–0.460) | (0.236–0.552) | (0.556–1.346) | |||||||||
3. | rs 11200638 | ACC | 0.720 | 0.651 | 0.452 | 1.42×10−7 | 3.129 | 1.0×10−4 | 2.277 | 0.1557 | 1.374 |
(2.033–4.816) | (1.498–3.461) | (0.884–2.136) | |||||||||
rs 55928386 | GCC | 0.134 | 0.142 | 0.269 | 9.0×10−4 | 0.422 | 0.0019 | 0.436 | 0.842 | 0.944 | |
rs 2672598 | (0.248–0.719) | (0.258–0.737) | (0.522–1.704) |
For the polymorphisms that were not a single nucleotide change, the wild type was denoted as 1 and the variant denoted as 2.