Table 3.
Biological pathways displaying down-regulation (compared with normal mucosa) in SPLs, LPLs, and CRCs
| |
|
Nominal p-values of enrichment scores† |
||
|---|---|---|---|---|
| Pathways | n* | N vs SPL | N vs LPL | N vs CRC |
| 1) BIOCARTA AT1R PATHWAY |
50 |
0.047 |
- |
- |
| 2) BIOCARTA BIOPEPTIDES PATHWAY |
81 |
0.027 |
- |
- |
| 3)BIOCARTA IL3 PATHWAY |
20 |
0.044 |
- |
- |
| 4) KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION |
51 |
0.029 |
- |
- |
| 5) KEGG CHEMOKINE SIGNALING PATHWAY |
216 |
0.042 |
- |
- |
| 6) KEGG GAP JUNCTION |
100 |
0.039 |
- |
- |
| 7) KEGG MAPK SIGNALING PATHWAY |
400 |
0.047 |
- |
- |
| 8) KEGG VASCULAR SMOOTH MUSCLE CONTRACTION |
152 |
0.037 |
- |
- |
| 9) REACTOME FORMATION OF PLATELET PLUG |
236 |
0.017 |
- |
- |
| 10) REACTOME FRS2 MEDIATED ACTIVATION |
23 |
0.049 |
- |
- |
| 11) REACTOME HEMOSTASIS |
348 |
0.024 |
- |
- |
| 12) REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS |
256 |
0.046 |
- |
- |
| 13) REACTOME NRAGE SIGNALS DEATH THROUGH JNK |
61 |
0.041 |
- |
- |
| 14) REACTOME PLATELET ACTIVATION |
208 |
0.018 |
- |
- |
| 15) REACTOME RHO GTPASE CYCLE |
132 |
0.046 |
- |
- |
| 16) REACTOME SEMAPHORIN INTERACTIONS |
89 |
0.031 |
- |
- |
| 17) SA PTEN PATHWAY |
27 |
0.027 |
- |
- |
| 18) REACTOME CAM PATHWAY |
32 |
- |
0.042 |
- |
| 19) REACTOME G ALPHA Z SIGNALLING EVENTS |
13 |
- |
0.04 |
- |
| 20) REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA |
23 |
- |
0.037 |
- |
| 21) REACTOME G PROTEIN ACTIVATION |
34 |
- |
0.02 |
- |
| 22) REACTOME NEURORANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL |
115 |
- |
0.035 |
- |
| 23) BIOCARTA NUCLEARRS PATHWAY |
22 |
- |
- |
0.009 |
| 24) KEGG ASCORBATE AND ALDARATE METABOLISM |
19 |
- |
- |
0.008 |
| 25) KEGG DRUG METABOLISM CYTOCHROME P450 |
71 |
- |
- |
0.017 |
| 26) KEGG DRUG METABOLISM OTHER ENZYMES |
51 |
- |
- |
0.045 |
| 27) KEGG LONG TERM POTENTIATION |
94 |
- |
- |
0.024 |
| 28) KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 |
69 |
- |
- |
0.018 |
| 29) KEGG NICOTINATE AND NICOTINAMIDE METABOLISM |
26 |
- |
- |
0.047 |
| 30) KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS |
24 |
- |
- |
0.009 |
| 31) KEGG NITROGEN METABOLISM |
28 |
- |
- |
0.024 |
| 32) KEGG RETINOL METABOLISM |
59 |
- |
- |
0.028 |
| 33) KEGG STARCH AND SUCROSE METABOLISM |
54 |
- |
- |
0.014 |
| 34) REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS |
62 |
- |
- |
0.049 |
| 35) REACTOME ETHANOL OXIDATION |
8 |
- |
- |
0.012 |
| 36) REACTOME GLUCURONIDATION |
15 |
- |
- |
0 |
| 37) REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION |
9 |
- |
- |
0.039 |
| 38) REACTOME PHASE II CONJUGATION |
62 |
- |
- |
0.036 |
| 39) BIOCARTA HDAC PATHWAY |
44 |
0.022 |
0.041 |
- |
| 40) KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES |
37 |
0.041 |
0.037 |
- |
| 41) REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING |
37 |
0.022 |
0.01 |
- |
| 42) REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 |
31 |
0.01 |
0.01 |
- |
| 43) REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 |
24 |
0.028 |
0.021 |
- |
| 44) REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION |
42 |
0.046 |
0.028 |
- |
| 45) REACTOME GLUCAGON TYPE LIGAND RECEPTORS |
39 |
0.042 |
0.036 |
- |
| 46) REACTOME GS ALPHA MEDIATED EVENTS IN GLUCAGON SIGNALLING |
30 |
0.015 |
0.012 |
- |
| 47) REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA |
30 |
0.034 |
0.027 |
- |
| 48) REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS |
18 |
0.045 |
0.042 |
- |
| 49) REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS |
14 |
0.049 |
0.018 |
- |
| 50) REACTOME OTHER SEMAPHORIN INTERACTIONS |
25 |
0.005 |
0.005 |
- |
| 51) REACTOME PLATELET ACTIVATION TRIGGERS |
73 |
0.028 |
0.047 |
- |
| 52) REACTOME SIGNAL AMPLIFICATION |
39 |
0.007 |
0.005 |
- |
| 53) REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS |
28 |
0.019 |
0.016 |
- |
| 54) REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR |
26 |
0.007 |
0.003 |
- |
| 55) KEGG GNRH SIGNALING PATHWAY |
150 |
0.017 |
- |
0.008 |
| 56) BIOCARTA STATHMIN PATHWAY |
34 |
- |
0.034 |
0.009 |
| 57) BIOCARTA PGC1A PATHWAY |
37 |
0.005 |
0.011 |
0.008 |
| 58) KEGG PPAR SIGNALING PATHWAY |
86 |
0.026 |
0.034 |
0.044 |
| 59) KEGG PROXIMAL TUBULE BICARBONATE RECLAMATION |
25 |
0.003 |
0.003 |
0.011 |
| 60) KEGG SULFUR METABOLISM |
18 |
0.047 |
0.03 |
0.038 |
| 61) REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY |
78 |
0.005 |
0.006 |
0.006 |
| 62) REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS |
23 |
0.011 |
0.012 |
0.022 |
| 63) REACTOME P2Y RECEPTORS | 18 | 0.009 | 0.01 | 0.036 |
* n = number of RefSeqs in the pathway.
† measured by RS analysis; only significant p-values (< 0.05) are shown.