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. 2012 Nov 1;13:136. doi: 10.1186/1471-2202-13-136

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Copyright ©2012 Mandela et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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KalSR^KO/KOmice have abnormal skeletal muscle ultrastructure. Diaphragm muscle from WT and KalSR^KO/KO male and female mice was prepared for electron microscopic analysis. Representative images showing alterations in muscle (A,B) and neuromuscular junction (C,D) architecture are shown. A sarcomere, with the A, I and Z bands marked, is shown in (A). E. KalSR^KO/KO mice showed increased sarcomere (t(4)=12,p<0.001), increased I-band (t(4)=19,p<0.001) and decreased Z-band (t(4)=12,p<0.01) length. F. Junctional folds, shown schematically, were quantified per μm of junctional membrane; KalSR^KO/KO mice showed a decrease in junctional fold density (t(4)=4 p<0.05).