Figure 4. Anti-tumor activity of pFasL.

Panel A: Tumor growth in mice having received subcutaneously 10⁵ A431 cells at day 0, and 0.1 mL of concentrated pFasL (white boxes) or pFasL-free control (grey boxes) locally at days 2 and 7 (n = 6 mice per group). Tumor volumes are expressed in mm³. Values are presented as median, 25^th and 75^th percentiles (horizontal line, bottom and top of boxes), and 10^th and 90^th percentiles (bottom and top range bars) (**p = 0.04, * p = 0.05). Panel B: Kaplan-Meier analysis of cumulative percentage of mice without detectable tumor,, xenografted with A431 cells and treated with pFasL (black circles) or pFasL-free control (black squares) (p = 0.02). n = 20 mice per group, from two experiments pooled.