Table 4. Outcome of treatment of culture-positive tuberculosis cases in Canada by drug susceptibility pattern of incident case isolate (1997–2008).
| Drug Susceptibility Pattern | OR (95% CI)‡ | |||||
| Outcome* | Total No. (%) | SusceptibleNo. (%) | ResistantNon-MDRNo. (%)† | MDRNo. (%) | (MDR vs S) | (R non-MDR vs S) |
| No. Assessed | 15993 | 14582 | 1234 | 177 | ||
| Cure/Tx Complete | 7582 (47.4) | 7006 (48.0) | 511 (41.4) | 65 (36.7) | 1.0 | 1.0 |
| Transferred Out | 262 (1.6) | 230 (1.6) | 27 (2.2) | 5 (2.8) | 2.34 (0.73, 5.83) | 1.61 (1.03, 2.43) |
| Death | 964 (6.0) | 904 (6.2) | 54 (4.4) | 6 (3.4) | 0.72 (0.25, 1.65) | 0.82 (0.60, 1.10) |
| Failure/Absconded/Tx Ongoing | 290 (1.8) | 243 (1.7) | 34 (2.8) | 13 (7.3) | 5.77 (2.87, 10.74) | 1.65 (1.11, 2.39) |
| Other | 117 (0.7) | 102 (0.7) | 13 (1.1) | 2 (1.1) | 2.11 (0.25, 8.14) | 1.75 (0.89, 3.15) |
| Unknown | 6778 (42.4) | 6097 (41.8) | 595 (48.2) | 86 (48.6) | 1.52 (1.09, 2.14) | 1.34 (1.18, 1.58) |
Abbreviations: No., number; vs, versus MDR multidrug-resistant; Tx Treatment.
Outcome definitions: Cure/Tx Complete refers to successful completion of TB therapy, as deemed by their treating physician; Transferred Out refers to patients whose care was initiated in Canada but subsequently continued in another country; Death refers to all-cause mortality during TB treatment; Failure refers to clinical or microbiologic evidence of ongoing disease despite completion of TB treatment; Absconded refers to patients lost to follow-up; Tx ongoing refers to patients remaining on therapy at the time of publication, having had a minimum of 3 years follow-up.
Refers to resistance to one or more first-line drugs but not meeting the definition of MDR.
Confidence Intervals calculated using Fisher’s exact methods; ORs reaching statistical significance, based on non-overlapping 95% CIs are highlighted in italics.