Table 1. IL-17A, IFN-γ and Foxp3 mRNA levels correlate in small intestinal mucosa of patients with untreated celiac disease (Untreated CD) but not in symptom-free celiac disease patients on gluten-free diet (Treated CD).
Untreated CD | Treated CD | |||
mRNA species compared: | r | P-value | r | P-value |
IL-17A versus IFN-γ1 | 0.532 | 0.05 2 | 0.01 | NS3 |
IL-17A versus Foxp3 | 0.61 | 0.02 | 0.10 | NS |
IL-17A versus IL-10 | 0.42 | NS | 0.20 | NS |
IL-17A versus TGF-β1 | 0.12 | NS | 0.18 | NS |
Foxp3 versus IFN-γ | 0.02 | NS | 0.38 | NS |
Foxp3 versus IL-10 | 0.27 | NS | 0.17 | NS |
Foxp3 versus TGF-β1 | 0.04 | NS | 0.52 | 0.02 |
mRNA expression levels were compared in each individual sample.
r- and P-values obtained by correlation analysis between indicated mRNA species as determined by two-tailed Spearman rank correlation test.
NS = not significant, P-value >0.05.