Table 1. Mean concentration of fasting glucose, insulin and HOMA-IR scores in antipsychotic drug treated rats.
| Antipsychotic Drug | Measure | Treatment Dose (mg/kg) | |||||
| Asenapine | 0 | 0.01 | 0.05 | 0.1 | 0.5 | 1.0 | |
| G0 | 5.1±0.3 | 4.9±0.3 | 5.1±0.2 | 5.0±0.1 | 5.4±0.4 | 4.8±0.2 | |
| I0 | 24.6±5.7 | 16.3±2.2* | 21.7±3.0 | 20.4±3.1 | 29.7±4.4 | 33.3±3.5 | |
| HOMA-IR | 5.7±1.5 | 3.4±0.4* | 4.9±0.7 | 4.5±0.7 | 7.2±1.3 | 7.2±1.0 | |
| Iloperidone | 0 | 0.03 | 0.5 | 1.0 | 5.0 | 10.0 | |
| G0 | 4.6±0.2 | 4.9±0.2 | 4.6±0.2 | 4.9±0.2 | 5.1±0.2 | 5.2±0.3 | |
| I0 | 21.6±3.6 | 21.6±2.6 | 28.2±5.0 | 40.1±4.9* | 44.9±3.6* | 58.8±7.7* | |
| HOMA-IR | 4.6±0.8 | 4.7±0.5 | 5.9±1.2 | 8.8±1.2* | 10.2±0.8* | 13.8±2.2* | |
| Olanzapine | 0 | 0.1 | 0.5 | 1.5 | 5.0 | 15.0 | |
| G0 | 5.0±0.2 | 5.3±0.2 | 5.3±0.3 | 5.7±0.3 | 5.2±0.2 | 5.0±0.2 | |
| I0 | 19.7±1.7 | 32.5±6.0 | 35.9±5.7 | 36.3±2.7 | 41.4±6.6* | 47.8±5.8* | |
| HOMA-IR | 4.5±0.5 | 7.8±1.5 | 8.7±1.6 | 9.2±1.1 | 9.6±1.5 | 10.8±1.5 | |
I0 = fasting insulin levels (µU/ml); G0 = fasting glucose levels (mmol/L); HOMA-IR = homeostasis model assessment of insulin resistance (µU⋅mmol)/(ml⋅L).
Rats were treated with five separate doses of asenapine, iloperidone, olanzapine or vehicle. Values represented as means ± SEM at t = 30 min during the IGTT.
*
indicates different from vehicle-treated animals, p<0.05.