Figure 1. Schematic diagram of the model for mechanical stimulus transmission through an actin stress fiber in Hwang and Barakat.¹¹ The integrin is positioned at and the nuclear edge at . An actin stress fiber of length directly links the integrin to the nucleus. A prestress is generated due to myosin motor activity and is assumed to be uniformly distributed throughout the stress fiber. Forces are applied to the stress fiber at a location close to the integrin () in the direction (A) orthogonal to the stress fiber axis and (B) along the stress fiber axis.