Figure 1. SorLA-WT expression, but not sorLA-FANSHY→6A, mediates co-localization between retromer and APP. SH-SY5Y cells transfected with either sorLA-WT (left panel) or sorLA-FANSHY→6A (right panel) were stained with an antibody against the extracellular domain of sorLA (in red), or the endogenously expressed proteins APP (in green) and Vps35 (in blue). Co-localization of the trimeric complex between APP, Vps35 and sorLA-WT is indicated by white arrow heads.